Signal Transduction in T Cells
Abstract
Rapid progress was during the past year in the delineation of the nature of the initial biochemical events triggered by the T-cell antigen receptor. Antigen-mediated activation of phospholipase C was demonstrated to require protein tyrosine phosphorylation and, most surprising, activation of the Ras family of signal transduction molecules was shown to closely follow simulation of the T-cell antigen receptor. Major controversy continues over which events are relevant to the various effector functions of T-cells.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1991
- Accession Number
- ADA240902
Entities
People
- Carl H. June
Organizations
- Naval Medical Research Center