Melatonin, the Pineal Gland and Circadian Rhythms

Abstract

This project had two interrelated thrusts, both of which are currently in progress. The first, Cellular mechanisms of melatonin's action using an in vitro hypothalamic slice preparation , has been set up. Our initial data indicate a modest but significant decrease in the relative LGU by 10 nM and 1 uM melatonin but not 10 pM melatonin at CT9-10. The second major thrust of this project. The pineal gland's role in mammalian circadian organization , is progressing very well. This study indicates that, although pinealectomy has no effect on rat circadian rhythms is LD or constant darkness (DD), the surgery completely disrupts circadian rhythms is constant light.

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Document Details

Document Type
Technical Report
Publication Date
Aug 19, 1991
Accession Number
ADA241617

Entities

People

  • Vincent M. Cassone

Organizations

  • Texas A&M University

Tags

DTIC Thesaurus Topics

  • Air Force
  • Air Force Facilities
  • Analysis Of Variance
  • Anesthesia
  • Biology
  • Birds
  • Brain
  • Chemical Compounds
  • Chronobiology
  • Circadian Rhythms
  • Computer Programs
  • Endocrine Glands
  • Entrainment
  • Glands
  • Hormones
  • Incubation
  • Melatonin

Fields of Study

  • Biology

Readers

  • Exercise and Sports Science.
  • Geochemistry
  • Technical Research and Report Writing.