Pharmacokinetic Models for the Elimination of Drinking Water Contaminants from the Body,

Abstract

Humans are exposed to a variety of chemicals in drinking water. These chemicals or their toxic metabolites could elicit adverse biological effects in target tissues if present at sufficient concentrations and exposure durations. Understanding the metabolism and pharmacokinetics of these chemicals thus can provide a better evaluation of biological effects associated with environmental exposure. In this research project, an attempt is made to understand the pharmacokinetic behaviour of representative chemicals and to identify those models most suitable in estimating the time period required to excrete drinking water contaminants at concentrations specified by One-day, Ten-day, Longer-term, and lifetime exposure Health Advisories. In addition, available pharmacokinetics models are critically evaluated for their strengths and weaknesses in achieving the objective specified.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 1990
Accession Number
ADA241688

Entities

People

  • Allan Marcus
  • Nancy J. Balter
  • Nicolas P. Hajjar
  • Sorell L. Schwartz

Organizations

  • Battelle Memorial Institute

Tags

DTIC Thesaurus Topics

  • Alkenes
  • Biomedical Research
  • Blood
  • Chemistry
  • Chlorides
  • Computational Science
  • Computer Programs
  • Computer Simulations
  • Digestive System Processes
  • Environmental Exposure
  • Environmental Protection
  • Halogenated Hydrocarbons
  • Laboratory Animals
  • Metabolism
  • Organic Compounds
  • Pest Control
  • Risk Analysis

Fields of Study

  • Environmental science
  • Medicine

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