Extrathalmic Modulation of Cortical Function
Abstract
The studies we have completed to data suggest that monkey auditory and visual P300s in passive and in active operant conditions exhibit morphological and functional characteristics similar to those observed in human subjects. The role of NA-LC in the genesis of P300 was examined in the present study by recording ERPs in squirrel monkey (Saimiri sciureus) before and after systemic administrations of the alpha-2 adrenergic agonist, clonidine, in doses that are known to suppress the electrophysiological activity of LC neurons. Clonidine significantly decreased the area and increased the latency of P300- like potentials without affecting other ERP components. It also increased EEG power in the alpha range (8-12Hz) and decreased power in the upper beta range (20-40 Hz) which leaving performance unaffected. Administration of clonidine, however, had no effect on the amplitude, area, or latency of the visual P300 component.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 06, 1991
- Accession Number
- ADA241706
Entities
People
- Jaime A. Pineda
- Stephen L. Foote
Organizations
- University of California, San Diego