The Role of Cytomegalovirus in the Development of ARC-AIDS
Abstract
This was a study to determine whether cytomegalovirus (CMV) might be a cofactor with the human immunodeficiency virus type 1 (HIV-1) to accelerate immunosuppression. Over seven hundred healthy HIV-1 seropositive U.S. Air Force personnel consented to be a part of this study, of whom 63% were initially CMV- seronegative. The CMV-seroconversion rate among seronegatives was 19%/yr, indicating primary infection through close personnel contacts. Three groups of subjects were studied to compare their rates of CD4+T-cell decline: CMV- seronegatives, CMV-seropositives, and CMV-seroconverters. CD4+T-cell depletion in CMV-seropositive subject whose cell numbers were decreasing has been significantly faster than in CMV-seronegatives (P=0.003). Using a similar mean of analysis, herpes simplex virus type 2 (HSV-2) infection was not found to be associated with decline in CD4+T cell depletion in HIV-1 infected people. The variations in the rate of CD4+T-cell decline among CMV-seropositive subject were significantly greater than among CMV-seronegative subjects.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 30, 1991
- Accession Number
- ADA241733
Entities
People
- Kendall O. Smith
Organizations
- University of Texas Health Science Center at San Antonio