Entrapping of Hydrophobized Plague Capsular Antigen into the Large Unilamellar Liposomes
Abstract
Liposomes, having adjuvant properties increase the body's immune response to the antigens introduced with them. The immunopotentiating effect depends on the quantity of antigen immobilized in the liposomes, the presence of it on the outer surface of the membrane, lipid composition, size of the vesicles and other conditions. Hydrophilic proteins are adsorbed on the liposome membrane in a small quantity, which reduces immunogenicity of the preparation. Consequently the problem emerged of immobilizing proteins on the outer surface of the vesicles. Diverse methods have been developed in recent years for fixing proteins on the liposome membrane.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1991
- Accession Number
- ADA241775
Entities
People
- N. G. Plekhanova
- V. I. Smirnova
- V. I. Zakrevskiy
Organizations
- United States Army Medical Research Institute of Infectious Diseases