Study of Protective Properties of Antigen-Containing Liposomes of Varying Lipid Composition in Plague
Abstract
Inclusion of antigens in liposomes in many cases makes it possible to produce an immune response of a higher level. This approach is very promising in terms of creating highly immunogenic preparations to prevent infectious illnesses. There has been very little study of the mechanism for the stimulating effect of liposomes. However, there is no doubt that immunogenicity of the preparation is determined a great deal by the nature of interaction between the antigen-containing liposomes and the immunocompetent cells. The physicochemical properties of the liposome membrane depending on its phospholipid composition play a significant role in this case. We previously demonstrated the higher protective properties of the capsule antigen of the plague pathogen when it is included in liposomes.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1991
- Accession Number
- ADA241778
Entities
People
- N. G. Plekhanova
- V. I. Zakrevskiy
Organizations
- United States Army Medical Research Institute of Infectious Diseases