The Effects of Exercise on Pharmacokinetics and Pharmacodynamics of Physostigmine in Rats
Abstract
This report deals with the effect of acute and trained exercise on pharmacodynamics (cholinesterase activity), pharmacokinetics and biochemical parameters in the rat after physostigmine (Phy) administration. Dose-response studies of Phy and ChE inhibition in vivo indicated that a dose of 70 micrograms/kg of Phy inhibited about 30 % Che activity in RBC. This dose was used throughout these exercise studies in consultation with USAMRDC. The oxygen consumption, respiratory exchange ratio (RER) and heat production showed a positive linear relationship in young and adult rats at different levels of exercise. However, significant differences were found in oxygen consumption and caloric expenditure in young vs. adult rats. Different levels of acute exercise affect the ChE activity in RBC and heart and alter the Phy-induced ChE activity in RBC and brain.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 15, 1991
- Accession Number
- ADA241867
Entities
People
- L. Fitzpatrick
- M. Dasilva
- P. Buckenmeyer
- S. M. Somani
- S. N. Dube
Organizations
- Southern Illinois University School of Medicine