Biophysical Techniques for Examining Metabolic, Proliferative, and Genetic Effects of Microwave Radiation
Abstract
This project was undertaken to prepare for a comprehensive research effort examining metabolic, proliferative, and genetic effects of microwave radiation. To accomplish this task, preliminary studies have been performed with 4 cells systems; Chinese hamster ovary (CHO) cells, AS52 Chinese hamster cells (heterozygous at the xanthine-guanine phosphoribosyl transferase (XGPRT) locus), 244B proliferating human lymphoblastoid cells, and freshly isolated peripheral lymphocytes. The thermal response of the 244B cells has been carefully examined, and an initial characterization of the membrane markers, membrane permeability, and cell cycle distribution of these cells undertaken. The absence of the induction of chromosome aberrations in CHO cells, after exposure to 850 MHz pulsed wave (PW), 18mW/cm2 (specific absorption rate (SAR) 14.4 W/kg) radiofrequency radiation (RFR), or after exposure to 1,200 MHz PW (220 W -300 W net forward power; SAR 24.33 W/kg RFR, is reported. The survival response of the AS52 cells, after simultaneous treatment at 37 C or 40 C, with and without mitomycin or adriamycin, is described. The survival of the AS52 cells after X- ray exposure at low and high dose rates is also described.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1991
- Accession Number
- ADA241903
Entities
People
- Martin L. Meltz
Organizations
- Georgia Tech Research Corporation