Kullback-Leibler Information for Ordering Genes Using Sperm Typing and Radiation Hybrid Mapping

Abstract

Two technologies applicable to gene mapping are those of sperm typing and radiation hybrid mapping. Sperm typing makes use of the polymerase chain reaction, a biochemical technique which allows enormous amplification (production of multiple copies) of small, selected DNA fragments from a single chromosome. A sample of sperm from a single donor is analyzed to see which alleles (distinct forms of the various genes) are present in the individual sperms. The frequencies with which the various possibilities occur can be used to supply estimates of the ordering and of the recombination probabilities among the genes for which that donor is heterozygous (having different alleles of the same gene.)

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1991
Accession Number
ADA241982

Entities

People

  • Herman Chernoff

Organizations

  • Harvard University

Tags

Communities of Interest

  • Materials and Manufacturing Processes

DTIC Thesaurus Topics

  • Abstracts
  • Chain Reactions
  • Chemical Reactions
  • Chromosomes
  • Classification
  • Intervals
  • Markov Processes
  • Notation
  • Observation
  • Peak Values
  • Permutations
  • Polymerase Chain Reaction
  • Probability
  • Probability Distributions
  • Random Variables
  • Security
  • Universities

Fields of Study

  • Biology

Readers

  • Computational Linguistics
  • Molecular Genetics
  • Regression Analysis.