Development of a Therapeutic Agent for Wound-Healing Enhancement

Abstract

During this quarter we synthesized and purified three peptides, one from PDGF A-chain sequence and two from PDGF B-chain sequence. During this quarter we conducted cell binding experiments and assays for mitogenesis. Competitive receptor binding assays were performed on four peptides using NIH 3T3 cells. None of the peptides tested so far showed any binding. We tested two peptides at three doses and two at four doses. In the future, we will test peptides initially at three doses. Active peptides will be tested at four or more doses.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1991
Accession Number
ADA242529

Entities

People

  • Amrit K. Judd

Organizations

  • SRI International

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Assays
  • Bioassay
  • Casualties
  • Chemistry
  • Combat Casualty Care
  • Inhibition
  • Organic Chemistry
  • Sequences
  • Thymidines
  • Wound Healing

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.
  • Molecular and Cellular Biochemistry
  • Toxicology/Environmental Toxicology