An Experimental Brain Missile Wound: Ascertaining Pathophysiology and Evaluating Treatments to Lower Mortality and Morbidity

Abstract

Cerebral ischemia does not occur following a brain wounding provided that ICP is < 60 mmHg. Rather focal hyperperfusion occurs. Mechanical and chemical control of CBF are disturbed following brain wounding but these disturbances have wide regional variations. The missile-wounded brain may show severe CBF reductions with even a mild fall in MABP. No reflow follows cerebral ischemic occurring after frain wounding. Brain wounding is associated with decreased brain stem and hypothalamic biogenic amines especially epinephrine. This seems to be a part of a generalized stress response. Free radicals appear in the brain within minutes of brain injury.

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Document Details

Document Type
Technical Report
Publication Date
Jun 04, 1991
Accession Number
ADA242809

Entities

People

  • Michael E. Carey

Organizations

  • LSU Health Sciences Center New Orleans

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Amines
  • Blood
  • Blood-Brain Barrier
  • Brain
  • Brain Injuries
  • Cardiovascular Physiological Phenomena
  • Cardiovascular System
  • Cerebral Edema
  • Cerebrovascular Disorders
  • Chemical Synthesis
  • Chemistry
  • Craniocerebral Trauma
  • Neurons
  • Neurosciences
  • Organic Chemistry
  • Vitamin C

Fields of Study

  • Medicine
  • Psychology

Readers

  • Cardiovascular Physiology
  • Trauma Surgery or Emergency Medicine.