Evaluation of Liposome-Encapsulated Hemoglobin/LR16 Formulations as a Potential Blood Substitute
Abstract
Two summary sheets show the structures of several, new LR16 analogues recently synthesized. Preliminary testing has shown compounds 19, 22, and 25 to be active, achieving P50 values in LEH suspensions of 29.5, 28.5, and 21.0 mm Hg, respectively, at drug concentrations of 3 mM. The two lists of structures are followed by the experimental section outlining synthetic methodologies. The final three pages summarize a synthetic scheme and NMR data concerning our first analogue which contains a quaternary, permanently-charged nitrogen moiety (which should significantly reduce drug leakage from liposome). We are presently testing the ability of this agent to modulate the P50 value of hemoglobin.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 08, 1991
- Accession Number
- ADA243075
Entities
People
- Thomas G. Burke
Organizations
- Ohio State University