Immunological Approach to the Identification and Development of Vaccines to Various Toxins
Abstract
Murine monoclonal anti-saxitoxin and anti-ricin antibodies capable of protecting against the in vitro toxicity of saxitoxin and ricin, respectively, have been generated. These protective anti-toxin (Ab1) antibodies are being used to induce the production of internal image monoclonal anti-idiotypic antibodies (Ab2) which may serve as vaccines in the induction of active and protective immunity against these toxins. The murine responses to synthetic peptides homologous to immunogenic amino acid sequences of the ricin A and B chains have also been investigated either singly or in combination with the aim of developing a subunit vaccine against ricin in vivo toxicity.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 30, 1991
- Accession Number
- ADA243278
Entities
People
- Deborah L. Armstrong
- Patrick Kanda
- Tran C. Chanh
Organizations
- Texas Biomedical Research Institute