Carboxylesterases of the Testes: Role in Activation of Toxicants
Abstract
Organ specific distribution of carboxylesterases (Western blotting) was determined to be liver lung = testes = fat pancreas kidney. Carboxylesterase distribution among cell types of the testes was examined by in situ hybridization techniques. Results were inconclusive, as both the probe and the control hybridized to tissues macromolecules. More refinement of this techniques should provide better results. Other accomplishments include examination of the down-regulation of carboxylesterase levels by glucocorticoids. Apparently esterase levels are most dramatically down-regulated (approximately 6-fold) by dexamethasone phosphate (60 mg/kg x 5 days, i.p.) in the testes compared to the other tissues containing this enzyme.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 30, 1990
- Accession Number
- ADA243379
Entities
People
- Joan W. Cassedy
- Rochelle M. Long
Organizations
- Society of Toxicology