Physiologically Based Pharmacokinetic Model for Evaluating a Simulant for Toxic Gases in Primates

Abstract

Chloropentafluorobenzene (CPFB) has been proposed as an innocuous simulant for the uptake of toxic gases. Exposure to CPFB in a training exercise could be inferred afterwards from a measurement of CPFB in expired breath. To understand the relationship between exposure and measurement, we have developed a physiologically based pharmacokinetic (PBPK) model for CPFB in primates. To test the model, inhalation exposures were conducted on anesthetized rhesus monkeys. CPFB concentration in expired breath was measured during and after exposure. Simulations of CPFB uptake and clearance agreed with experimental measurements in seven of eight monkeys. A human version of the model was used to simulate exposures consisting of a single breath or a few breaths. By showing a measurable CPFB concentration in expired breath after several hours of clearance, simulations with the human model indicated the suitability of CPFB as a simulant for toxic gases.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1990
Accession Number
ADA243480

Entities

People

  • A. Vinegar
  • W. D. Crank

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Air Force
  • Air Force Facilities
  • Animals
  • Biomedical Research
  • Catheterization
  • Chemical Warfare
  • Chemical Warfare Agents
  • Chemistry
  • Clearances
  • Laboratory Animals
  • Measurement
  • Monkeys
  • Primates
  • Rhesus Monkeys
  • Simulations
  • Toxic Hazards

Fields of Study

  • Environmental science

Readers

  • Toxicology/Environmental Toxicology

Technology Areas

  • AI & ML
  • AI & ML - Bayesian Inference