Molecular Recognition in Gels, Monolayers, and Solids

Abstract

This paper describes work in four area:affinity electrophoresis of carbonic anhydrase in cross-linked polyacrylamide-derived gels containing immobilized derivatives of aryl sulfonamides; inhibition of the hemagglutination of erythrocytes induced by influenza virus using water-soluble polyacrylamides bearing sialic acid groups; the application of self-assembled monolayers (SAMs) of alkyl thiolates on gold to the study of protein adsorption on organic surfaces; and the use of networks of hydrogen bonds to generate new classes of non-covalently assembled organic materials, both in solution and in crystals. This paper summarizes research in two areas of molecular recognition:affinity polymers and molecular self assembly. We illustrate these areas by examples drawn from affinity gel electrophoresis, soluble synthetic macromolecular inhibitors of binding of influenza virus to erythrocytes protein adsorption on self assembled monolayers and self assembling hydrogen bonded molecular aggregates.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 1991
Accession Number
ADA243488

Entities

People

  • Christopher T Seto
  • James K. Chen
  • Kevin L. Prime
  • Walther Schmid
  • Yen-ho Chu

Organizations

  • Harvard University

Tags

DTIC Thesaurus Topics

  • Amides
  • Biochemistry
  • Biomedical And Dental Materials
  • Chemical Analysis
  • Chemical Compounds
  • Chemical Synthesis
  • Chemistry
  • Crystal Structure
  • Engineering
  • Materials
  • Military Research
  • Monomolecular Films
  • Organic Chemistry
  • Polymers
  • Self Assembled Monolayers
  • Self Assembly
  • Sialic Acids

Fields of Study

  • Chemistry

Readers

  • Molecular and Cellular Biochemistry
  • Polymer Science and Technology
  • Virology (or Medical Virology).