Post-Doctoral Research Award

Abstract

For the embryolethality tests, semicarbazide and isoniazid showed a slightly less than additive embryolethal response. Potentially different lethal modes of action may be observed for compounds that are thought to be teratogenic by the same mode of action. For the embryolethal binary mixture test of hydroxyurea and isoniazid the 3:1 mixture showed an antagonistic response, while the 1:1 and 1:3 mixtures were response additive, as expected. The antagonistic response may have been the result of poorer absorption of hydroxyurea by the severely malformed embryos, as isoniazid had a much greater concentration (in mg/L) than did hydroxyurea, even though the effective (lethal) concentration for hydroxyurea was nearly three times that for isoniazid. Short-chain carboxylic acids showed concentration additive joint actions for induction of malformation. Combinations of DNA synthesis inhibitors showed response additive to antagonistic joint actions ay malformation-inducing concentration.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 1988
Accession Number
ADA243549

Entities

People

  • Joan W. Cassedy

Organizations

  • Society of Toxicology

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Absorption
  • Acids
  • Anticonvulsants
  • Butyric Acids
  • Carboxylic Acids
  • Data Analysis
  • Developmental Biology
  • Embryos
  • Environmental Health
  • Enzyme Inhibitors
  • Inhibition
  • Inhibitors
  • Retinoic Acids
  • Statistical Analysis
  • Teratology
  • Test Methods
  • Toxic Actions

Readers

  • Marine Ecological Systems Migration
  • Toxicology/Environmental Toxicology