Stereospecificity of Antidotes and Their Mechanism of Action in Intoxications with Organophosphorus Anticholinesterases.
Abstract
Our program during the grant period has mainly been concerned with studies on: (1) Effect of antidotes such as l-hyoscyamine and atropine, diazepam, and Hl-6, separately and in combinations, on the dynamics of acetylcholine. We found that diazepam counteracts the increased rate of synthesis and release of acetylcholine induced by l-hyoscyamine. The addition of diazepam to conventional atropine-oxime therapy is therefore more effective in cases of organophosphate intoxications. Soman-intoxicated mice pretreated with the three-drug combination show no cholinergic symptoms and have a normal turnover of acetylcholine. (2) Influence of cholinergic substances on the functional muscarinic-receptor pool. Diazepam was found to decrease the size of the active receptor pool, which may lead to the observed effect on the dynamics of acetylcholine and choline.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 28, 1991
- Accession Number
- ADA243678
Entities
People
- Bo. Holmstedt
- Bo. Karlen
- Ingrid. Nordgren
- Lena. Palmer