Autoradiographic Distribution and Applied Pharmacological Characteristics of Dextromethorphan and Related Antitissue/Anticonvulsant Drugs and Novel Analogs
Abstract
The objective of this project is to investigate the potential significance of the neuroprotective agent dextromethorphan, and its receptor, in normal and abnormal brain. Dextromethorphan is a non-opioid cough suppressant. It is as potent as codeine, but has the opposite steric configuration (i.e., it is dextrorotatory rather than levorotatory), and possesses none of the CNS pharmacology normally associated with opioids. The demonstration in 1981 of high affinity binding sites for dextromethorphan, which were distinct from any known neurotransmitter or neuromodulator sites, was followed by the discovery that dextromethorphan also possessed significant anticonvulsant and neuroprotective properties.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 1991
- Accession Number
- ADA243953
Entities
People
- Bowery
- Kathryn Bevan
Organizations
- University of London