Neuropharmacological Characterization of Botulinum Neurotoxin
Abstract
The purpose of the work is to find drugs that will antagonize the actions of clostridial neurotoxins. Studies will be conducted initially on neuromuscular preparations, cells in culture, or other tissues obtained from laboratory animals. When a promising drug is identified, it will be tested as an antagonist of toxin action on human tissues. During the first half of the contract, experiments have been done to evaluate Zaprinast and other drugs that alter the levels or tissue distribution of c-GMP and its synthesizing and degrading enzymes. These substances have previously been reported to antagonize clostridial neurotoxins on a tissue culture line. The results have produced an unexpected outcome. The drugs antagonize toxins on one type of tissue preparation but not another. This unexpected finding may have important implications for understanding toxin action.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1991
- Accession Number
- ADA244091
Entities
People
- Lance L. Simpson
Organizations
- Thomas Jefferson University