Study of Compounds for Activity against Leishmania

Abstract

During the period covered by this report, a total of 75 compounds were tested for efficacy against Leishmania donovani infections in hamsters. A computer analysis of the data from the study of approximately 6000 compounds tested since this project was initiated in 1974 suggested a number of compounds with sufficient promise to warrant further study during this contract period. The 8-aminoquinolines were the most active compounds studied, one of which was 100% suppressive at dosage levels as low as 13mg/kg. Six phenanthrene methanols as well as two dibenzopyrroles selected for study were not highly active against L. donovani, and some were toxic.

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Document Details

Document Type
Technical Report
Publication Date
Oct 27, 1990
Accession Number
ADA244744

Entities

People

  • V. B. Waits
  • W. L. Chapman Jr
  • William L. Hanson

Organizations

  • University of Georgia Research Foundation

Tags

DTIC Thesaurus Topics

  • Alcohols
  • Animals
  • Body Weight
  • Cells
  • Computer Programs
  • Computers
  • Contracts
  • Diseases And Disorders
  • Infection
  • Infectious Diseases
  • Leishmania
  • Leishmaniasis
  • Materials
  • Medical Personnel
  • Methanols
  • Parasites
  • Wound Infections

Readers

  • Parasitology and Pharmacology of Malaria.
  • Systems Analysis and Design