Evaluation of Liposome-Encapsulated Hemoglobin/LR16 Formulations as a Potential Blood Substitute

Abstract

Attached are two summary sheets showing the structures of several, new LR16 analogues recently synthesized with the support of Department of the Navy Grant No. N000014-90-J-1648. Preliminary testing has shown organic compounds to be active, achieving P50 values in LEH suspensions at drug concentrations of 3 mM. Testing of the organic compounds listed on the second sheet (01 series) is presently underway. The two lists of structures is followed by the experimental section outlining synthetic methodologies. The final three pages of this report summarize a synthetic scheme and nuclear magnetic resonance data concerning our first analogue which contains a quaternary, permanently charged nitrogen moiety (which should significantly reduce drug leakage from liposome). We are presently testing the ability of this agent to modulate the P50 value of hemoglobin.

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Document Details

Document Type
Technical Report
Publication Date
Nov 08, 1991
Accession Number
ADA244806

Entities

People

  • Thomas G. Burke

Organizations

  • Ohio State University

Tags

DTIC Thesaurus Topics

  • Alcohols
  • Analogs
  • Blood Substitutes
  • Catalysts
  • Ethers
  • Hemoglobin
  • Magnetic Resonance
  • Melting Point
  • Methanols
  • Mixtures
  • Nuclear Magnetic Resonance
  • Organic Compounds
  • Precipitates
  • Propionic Acid
  • Pyridines
  • Silica Gels
  • Sodium Hydroxide

Readers

  • Instructional Design and Training Evaluation.
  • Molecular and Cellular Biochemistry