Acute and Subacute Toxicity of 7.5% Hypertonic Saline/6% Dextran-70 (HSD) in Dogs
Abstract
HSD is currently being evaluated in our laboratory as a resuscitation solution for the treatment of hypovolemia at a dose of 4 ml/kg body weight. Since a few reports of dextran toxicity, particularly of the kidney, have been cited in the literature, the present study evaluated the acute and subacute toxicity of HSD administered IV to beagle dogs. In the acute toxicity studies, animals were infused with a single dose of HSD or its components hypertonic saline (HS) or dextran (D-70), at the maximum tolerated dose (MTD; 20 ml/kg). Controls received Ringers lactate (RL). In aminotransferase (AT), asp AT and alkaline phosphatase (AP) were observed for the first 72 h. In most cases this increase was also observed in the HS above test solutions.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 18, 1991
- Accession Number
- ADA244808
Entities
People
- Charles E Wade
- Don W. Korte Jr.
- Gary M. Zaucha
- Michael A. Dubick
Organizations
- Letterman Army Hospital