Liquid Collagen Wound Coverings Award Number N00014-90-J-1797
Abstract
The current procedure involves freezing of collagen solutions by dripping the solution into liquid nitrogen and lyophilizing the beads thus generated. This is less than satisfactory, because it is extremely time consuming and the beads tend to compress and are not readily soluble. We have developed a liaison with Oregon Freeze Dry, which is the world's largest processor of freeze dried products (see brochure). This company is interested in expanding the use of freeze dry technology beyond the food industry and is thus interested in collaborating with us. They have freeze dried our collagen preparations at three different rates of freeze in order to vary the size of the ice crystals. As the ice crystals are removed, varying size voids are left in the collagen felt, permitting different rates of rehydration and solubilization. We have determined that a freezing rate of 1 per minute provides optimum rehydration characteristics, which are far better those of our laboratory freeze dried material. We are now packaging freeze dried wound covering material and will make this available to other hospitals.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 14, 1992
- Accession Number
- ADA245301
Entities
Organizations
- Oregon Health & Science University