Metalloporphyrin Complexes as Model Compounds for Cytochrome P-450

Abstract

Cytochrome P-450 is the collective name given to a family of heme protein oxygenases found in most eucaryotic organisms. The goals of this project were to explore the role of the thiolate ligand in the catalytic properties of the cytochrome P-450 enzymes and to develop synthetic chemical models of these enzymes. Three possible roles of the thiolate ligand were examined in this study: facilitation of oxygen-oxygen bond cleavage, stabilization of the high valent oxo complex, and moderation of oxygen atom transfer. It was found that the identity of axial ligand did not affect the rate or extent of catalytic oxidation. This provided no accurate comparison for evaluation of the first and third possible roles. It was found that the thiolate ligand actually destabilizes the high valent oxo complex, contrary to the second possible role.

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Document Details

Document Type
Technical Report
Publication Date
May 13, 1991
Accession Number
ADA245644

Entities

People

  • David L. Blazes

Organizations

  • United States Naval Academy

Tags

DTIC Thesaurus Topics

  • Alcohols
  • Alkanes
  • Alkenes
  • Amino Acids
  • Catalytic Oxidation
  • Chemical Reactions
  • Chemical Synthesis
  • Chemistry
  • Chlorides
  • Organic Chemistry
  • Oxidation
  • United States Naval Academy

Fields of Study

  • Chemistry

Readers

  • Molecular Genetics
  • Organic Chemistry
  • Organizational Psychology.