Study of Hydrazine Metabolism and Toxicity

Abstract

Hydrazine is an important chemical substance being used extensively in industry, as a rocket fuel and it is a metabolite of two widely used drugs. We have previously studied hydrazine toxicity and metabolism, recently using the technique of high resolution NMR. We have shown that hydrazine does not cause lipid peroxidation and causes depletion of ATP in the liver after hepatotoxic doses. The object of this project was to study the metabolism and disposition of hydrazine in vivo and in vitro in relation to the hepatotoxicity.

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Document Details

Document Type
Technical Report
Publication Date
Jan 10, 1992
Accession Number
ADA245755

Entities

People

  • J. A. Timbrell

Organizations

  • University of London

Tags

Communities of Interest

  • Weapons Technologies

DTIC Thesaurus Topics

  • Abstracts
  • Cells
  • Cellular Structures
  • Cytochromes
  • Digestive System Processes
  • Drinking Water
  • Electron Microscopy
  • Epithelial Cells
  • Gas Chromatography
  • Glycerides
  • Health Services
  • High Resolution
  • Hydrazines
  • Inhibition
  • Metabolism
  • Metabolites
  • Microsomes

Readers

  • Molecular and Cellular Biochemistry
  • Rocket Propulsion.
  • Toxicology/Environmental Toxicology