Evaluation of NO(X)-Induced Toxicity
Abstract
This report summarizes experimental approaches and the results of investigations of the pulmonary toxicity of (Nitrogen oxides x) that were conducted at the Los Alamos National Laboratory during FY91. Herein we describe: how ventilatory patterns are altered by the inhalation of high concentrations of nitrogen dioxide (NO2), how the ventilatory response(s) to (Carbon dioxide 2) are altered by the concurrent inhalation of high concentrations of NO2, the results of studies of the relative severities of pulmonary injury caused by NO2 when inhaled under resting and CO2 driven minute ventilations, assessments of the severity of NO2 induced lung injury in the context of actual inhaled doses, findings obtained about the relationship of the severity of NO2 induced injury in terms of exposure mass concentration and duration, how post exposure exercise can potentiate lung injury caused by short burst, high concentration NO2 exposure, the kinetics of lung free cell and biochemical changes in lavage fluids following exposure to a high concentration of NO2, and further refinements that have been made in our mathematical model that describes the accumulation and elimination of methemoglobin during and after exposure to nitric oxide (NO), respectively.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 20, 1991
- Accession Number
- ADA246022
Entities
People
- Bruce E. Lehnert
- Douglas M. Stavert
Organizations
- Los Alamos National Laboratory