Genetic Variation of HIV: Viral Load and Genotypic Diversity in Relation to Viral Pathogenesis and Treatment
Abstract
Elucidation of HIV-1 and HIV-2 pathogenesis and development of effective antiviral treatments and vaccines will require a thorough understanding of viral replication patterns, viral load, and the molecular details of viral variation occurring in natural infection. In this midterm report, we describe studies which address this important area of HIV biology. Our results show for the first time (1) the dynamic changes in viral replication that occur during natural infection from acute (CDC stage I) to chronic (CDC stage II-IV) disease; (2) the substantial changes in genotypic complexity (quasispecies) occurring with sexual transmission of HIV-1 and the subsequent establishment of viral persistence; (3) the genetic and biologic characteristics of HIV-1 proviruses closed gloves directly from uncultured human tissues.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 20, 1992
- Accession Number
- ADA246409
Entities
People
- George M. Shaw
Organizations
- University of Alabama