Regional Blood-Brain Barrier Responses to Central Cholinergic Activity
Abstract
Regional blood brain permeability-capillary surface area products and regional cerebral blood flows were significantly increased by subconvulsant and convulsant treatment with soman. These effects were dose-related and time- dependent. Some effects lasted as long as 1 week, even when subconvulsant doses were used. The pattern and intensity of effects were qualitatively and quantitatively different from those produced by pentylenetetrazol. Soman also produced marked neuropathology across wide brain regions. Combined anticonvulsant pretreatment with diazepam, HI6 and atropine failed to prevent much of the long-term cerebrovascular damage and neuropathology produced by soman. Strategies for enhancing the neuroprotective actions of this pretreatment are described. Seizure, regional cerebral blood flow, blood-brain barrier, Permeability, brain vascular space, pentylenetetrazol, cardiac output soman RAI
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 15, 1991
- Accession Number
- ADA246911
Entities
People
- Harold Goldman
- Robert F. Berman
Organizations
- Wayne State University