An Investigation of the Memory Response of the Local Immune System to Shigella Antigens
Abstract
During the past five years, our laboratory has investigated the secretory IgA memory response to shigella are taken up for antigen processing by the gut-associated lymphoid tissues. The uptake by M cells overlying lymphoid follicles in the gut may serve as a double-edged sword. Whereas this is the initial step in processing of the shigella antigen to develop a mucosal immune response, it is also a portal of entry through which pathogenic chigella prefer to pass and where they can replicate creating the ulcerations characteristic of human dysentery. The cellular basis for the secretory IgA response has been documented in the rabbit model. The role of T lymphocytes from GALT to help the B lymphocyte production of IgA against enterically primed antigens has been shown conclusively. It is especially interesting that these T helper cells can augment the response of B lymphocytes in the peripheral blood (a site not previously studied for this effect despite its availability). Further, we have established that a secretory IgA response against Shiga toxin can be elicited in our Thiry-Vella loop model in rabbits. RA I, Shigella, Mucosal Immunity, Secretory IGA, Bacteriology, Lab Animals, Rats, Rabbits, Immunology.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 10, 1991
- Accession Number
- ADA247107
Entities
People
- David F. Keren
Organizations
- University of Michigan