Involvement of Lipid Metabolism in Chemical Transmission Processes at Mossy Fiber Synapses
Abstract
In 1991 we continued our investigations on the involvement of membrane lipid metabolism in the presynaptic processes related to the evoked release of the neurotransmitter glutamate. In particular, we observed that the phospholipase A2-dependent release of arachidonic acid from mossy fiber membrane phospholipids may modulate transmitter secretion through interactions with protein kinase c (PKC). The activation of PKC may explain the previously observed facilitation of depolarization-evoked Ca2+ accumulation and glutamate release induced by exogenous arachidonate. These facilitory effects may be related to the induction of long-term synaptic potentiation, which is an accepted correlate of learning and memory. In addition, we obtained evidence that presynaptic receptor activation stimulates the synthesis of arachidonate- derived prostaglandins. Thus, the metabolism, of arachidonic acid may play a central role in presynaptic plasticity.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 29, 1992
- Accession Number
- ADA247198
Entities
People
- Robert V. Dorman
Organizations
- Kent State University