Indeterminate HIV-1 Western Blots: Etiology, Natural History and Psychological Reactions

Abstract

236 PERSONS (CASES) WITH PAST REACTIVE HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 (HIV-1) EIAS and indeterminate HIV-1 Western Blots (IWBS) were followed prospectively. Of the 159 cases followed > 6 months, 6 seroconverted (3.8% seroconversation risk). All 6 seroconverters reported HIV risk behaviors, all had p24 bands prior to seroconversion, and 5 of the 6 seroconverted within one month. HIV-1 culture, polymerase chain reaction, serum p24 antigen, and the recombinant assays, CBre 3 and Syva Microtrak, had specificities of 100%, 99.1%, 100%, 97.1%, and 100%, respectively. An algorithm for evaluation of persons with IWB is proposed. A case-control study demonstrated past positive tuberculin skin test, recent tetanus booster, autoantibodies, and parity were associated with IWBs. No cross-reactivity was seen with HTLV-1 or HIV-2. Cases reported significantly more anxiety than controls, due in large part to the IWB. High- risk cases reported more anxiety than low-risk cases. Informational brochures for counseling were designed.

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Document Details

Document Type
Technical Report
Publication Date
Sep 24, 1991
Accession Number
ADA247531

Entities

People

  • Connie Celum
  • Thomas Inui

Organizations

  • University of Washington

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Algorithms
  • Blood Donors
  • Chain Reactions
  • Chemical Reactions
  • Drug Abuse
  • Health Care
  • Health Services
  • Hiv Infections
  • Medical Personnel
  • Polymerase Chain Reaction
  • Proteins
  • Public Health
  • Sexually Transmitted Diseases
  • Skin Tests
  • Viruses

Readers

  • Immunology
  • Infectious Disease/Epidemiology
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.