Biophysical and Biochemical Mechanisms in Synaptic Transmitter Release
Abstract
The studies demonstrated that the injection of synapsin I, in addition to reducing the background spontaneous release of transmitter, produces a reduction of transmitter released by direct depolarization of the presynaptic terminal. Furthermore the spontaneous release mimics the time course of the reduction of the evoked release such that the two can be easily correlated. The effect of CaM kinase II injection produces an increased miniature frequency in parallel with the increase in evoked release without changing the time course of the miniatures. This indicated the probability of release was being enhanced both during spontaneous and evoked release, only increasing the likelihood of vesicular release. A similar type of calcium channel is also present for peptide secretion from the hypothalamus to the hyposphysis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 31, 1991
- Accession Number
- ADA247684
Entities
People
- Rodolfo R. Llinas
Organizations
- NYU Langone Health