Human Immune Response to Dengue Infections

Abstract

The purpose of this contract was to analyze human immune responses to dengue virus infections. To understand the role of immune responses in recovery from dengue virus infection and in the pathogenesis of dengue hemorrhagic fever and dengue shock syndrome, we have analyzed human CD4+ CD8- T cell responses to dengue virus, human CD8+ CD4- T cell responses to dengue viruses, activation of T lymphocytes in vivo in dengue virus infections, dengue virus infection of human cell lines, enhancement of dengue virus infection by antibodies to dengue virus, antibody-dependent enhancement of dengue virus infection mediated by bispecific antibodies, production of interferon by dengue virus infected cells, and induction of virus infected monocytes.

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Document Details

Document Type
Technical Report
Publication Date
Jun 30, 1991
Accession Number
ADA247958

Entities

People

  • Francis A. Ennis

Organizations

  • University of Massachusetts Medical School

Tags

DTIC Thesaurus Topics

  • Biological Factors
  • Blood
  • Cardiovascular System
  • Cell Line
  • Cells
  • Chemistry
  • Health Services
  • Hemorrhage
  • Interferon
  • Lymphocytes
  • Monocytes
  • Myeloid Cells
  • Phagocytes
  • Proteins
  • T Lymphocytes
  • Vaccines
  • Viruses

Fields of Study

  • Biology
  • Medicine

Readers

  • Immunology
  • Virology (or Medical Virology).