Analysis and Synthesis of Adaptive Neural Elements and Assembles
Abstract
Between October 1, 1990 and September 30, 1991, progress was made in six areas. First, voltage-clamp experiments investigated the modulation of the voltage-dependent K+ current (IK,v) by serotonin (5-HT). Second, a computer program that is a general-purpose Simulator for Neural Networks and Action Potentials (SNNAP) was developed. Third, extensions were made to the single-cell model of associative learning by incorporating Hodgkin-Huxley type membrane currents, descriptions of the modulation of membrane currents by 5-HT, and a model of intracellular Ca2+ diffusion. Fourth, SNNAP was used to investigate the role of interneurons in determining the intensity and duration of motor neuron responses that mediate the tail-withdrawal reflex. Fifth, experiments characterized the synaptic interactions among the neurons of a central pattern generator (CPG) that underlies aspects of feeding behavior. Sixth, SNNAP was used to begin simulating the neurons and synaptic connections of the feeding CPG. In addition, work on the model of the bursting neuron R15 was completed.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 17, 1992
- Accession Number
- ADA248467
Entities
People
- John H. Byrne
Organizations
- McGovern Medical School