Malaria, Leishmaniasis and Shistosomiasis Vector Ecology, Transmission, Immunology and Prophylaxis in Kenya

Abstract

A malaria vaccine evaluation site at Saradidi, Kenya, has been characterized for epidemiological, entomological and demographic parameters over a two year period. The transmission of flaciparum malaria by Anopheles gambiae s.l. and A. funestus was found to be intense year-round. An evaluation of a WRAIR-developed malaria sporozoite vaccine, R32ToxA, was begun in April, 1990, with 38 pairs of volunteers. Leishmaniasis studies have described several parasite-vector-host relationships previously unreported in East Africa which may be important in the diagnosis or control of the disease. In particular, the isolation of two species of leishmania differing drug sensitivity profiles from a single patient is notable. Collaborative development of a vector-induced model for infection in vervet monkeys has significant potential for vaccine evaluation in a non-human model.

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Document Details

Document Type
Technical Report
Publication Date
Nov 06, 1991
Accession Number
ADA248501

Entities

People

  • Davy K. Koech

Organizations

  • Kenya Medical Research Institute

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Africa
  • Allergy And Immunology
  • Cells
  • Chemistry
  • Detection
  • Immunity
  • Infection
  • Leishmania
  • Leishmaniasis
  • Malaria
  • Parasites
  • Research Facilities
  • Salivary Glands
  • Sporozoites
  • Vaccines
  • Wound Infections

Fields of Study

  • Biology
  • Medicine

Readers

  • Infectious Disease/Epidemiology
  • Parasitology and Pharmacology of Malaria.
  • Vector-Borne Disease and Entomology

Technology Areas

  • Biotechnology