Xenobiotic Kinetics and Toxicity among Fish and Mammals
Abstract
The purpose of this project is to develop techniques that account for interspecies differences in the pharmacokinetics of xenobiotics. The hypothesis proposed is that toxicity occurs after exposure of the target organ to a characteristic concentration of toxicant for a particular period of time. To test the hypothesis, experiments are proposed to characterize the pharmacokinetics of three representative chemicals (lindane, pentachlorophenol and paraoxon) in small trout via water exposure, and large trout and rats via intravascular injection. Compartmental pharmacokinetic models will be used. The fraction of a dose of each test compound converted to each of its metabolites by the test animals will be determined to accounts for possible metabolic differences that might contribute to interspecies differences in toxicity. Binding of the test substances in blood to formed elements and plasma proteins will also be characterized.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 29, 1992
- Accession Number
- ADA248515
Entities
People
- William Hayton
Organizations
- Ohio State University