Modeling and Statistical Analysis of Bioassay Data

Abstract

The objective of the project, to date, has been to focus on biological issues believed to be important in converting toxin dosage to pre- cancerous and cancerous cells, and to translate these into appropriate quantitative mathematical terms. In particular, models that stem from the clonal expansion mechanisms identified by Moolgavkar and co-workers, cf, sample references (1979), (1983), have been studied, generalized (to account for possible variability or susceptibility between individual fish), and adapted for fitting to actual data. It appears to be widely believed that pre-cancerous conditions in an organ (the liver) occur as a result of cell clonal expansion, followed by a promotion (to tumor) event. Specific models for this has been proposed and developed by Moolgavkar and co-workers. More recent work is by C. J. Portier and co-workers.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1992
Accession Number
ADA249592

Entities

People

  • Donald P. Gaver Jr.

Organizations

  • Naval Postgraduate School

Tags

DTIC Thesaurus Topics

  • Bioassay
  • Biological Phenomena
  • Biomedical Research
  • Cancer
  • Data Analysis
  • Data Science
  • Differential Equations
  • Environmental Health
  • Equations
  • Information Science
  • Maximum Likelihood Estimation
  • Neoplasms
  • Probability
  • Random Variables
  • Risk
  • Risk Analysis
  • Statistical Analysis

Fields of Study

  • Mathematics

Readers

  • Aquatic Ecology
  • Oncology
  • Theoretical Analysis.