Investigation of the Hepatotoxic and Immunotoxic Effects of the Peroxisome Proliferator Perfluorodecanoic Acid.
Abstract
These studies examine the immunotoxic effects 8 days and 30 days following an intraperitoneal injection of PFDA. Histologic alterations observed in lymphoid organs at 8 days following PFDA treatment were more severe than those apparent at 30 days following PFDA treatment. Relative thymus weight was decreased at both 8 and 30 days following PFDA treatment, whereas relative spleen weight was decreased only at 8 days following PFDA treatment. Proliferation in response to Con A in preliminary 30 day and in vitro PFDA studies was decreased. IgG2a production, but not IgA or IgM production was decreased at 8 but not 30 days following PFDA treatment. DTH response at 8 and 30 days after PFDA treatment tended to be suppressed, although these data were not statistically significantly different. NK activity was increased at 30 but not 8 days following PFDA treatment and appeared to be anorexia-associated. Preliminary data on IL-2R, and spleen and thymic cell populations have been collected. Initial experiments have begun on the effect of PFDA on induction of hepatic Enoyl CoA hydratase. Perfluorodecanoic acid; immunotoxic; thymic atrophy; lymphoproliferation; delayed-type hypersensitivity; NK cell activity; lymphocyte subsets: interleukin 2
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 30, 1992
- Accession Number
- ADA250176
Entities
People
- Larry E. Mathes
- Melinda J. Tarr
Organizations
- Ohio State University