The Chronic Effects of JP-8 Jet Fuel Exposure on the Lungs.
Abstract
This research has resulted in four separate projects. The first was the exposure of Fischer 344 rats to JP-8 jet fuel for 7 or 28 days. This exposure resulted in changes in pulmonary function and lung chemical mediators, specifically Substance P, after 28 days of exposure. The second project dealt with blocking the increase in SP in these rats by a pretreatment regimen with capsaicin before jet fuel exposure. Capsaicin caused a further increase in lung permeability and a million-fold increase in airway sensitivity to histamine after the 7-day jet fuel exposure. The third project dealt with the effects of a 7-day jet fuel exposure in congenic mice who are deficient in the inducibility of the aryl hydrocarbon hydroxylase enzyme. These mice are relatively resistant to the effects of jet fuel-induced lung injury. The fourth project investigated the effects of the jet fuel exposure on secondary organs, specifically the liver, spleen, and kidneys. There were pathological differences in the liver, spleen, and kidneys between the 7-day jet fuel exposure group and baseline controls. However, some of these differences were not apparent in the 28-day exposure group, possibly indicating compensatory mechanisms to the exposure. JP- 8 Jet Fuel Exposure and its effects on the lungs and other organs.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 23, 1992
- Accession Number
- ADA250308
Entities
People
- Mark L. Witten
Organizations
- University of Arizona