Control of Circadian Behavior by Transplanted Suprachiasmatic Nuclei.

Abstract

A genetic mutation has been found that alters the free running period of the locomotor activity rhythm from the wild-type value of =24 hours to =20 hours in homozygous mutants. our data suggest the existence of two qualitatively different rhythmic outputs from the circadian oscillators contained with the SCN. One of these outputs stimulates the expression of locomotor activity producing activity rhythm's (which are seen within ), and the other suppresses the expression of activity, restricting its appearance to a temporally defined window and thereby defining the boundaries of p'. The idea that one function of a circadian output from the SCN is to suppress activity is novel.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Aug 15, 1991
Accession Number
ADA250442

Entities

People

  • Michael Menaker

Organizations

  • University of Virginia

Tags

DTIC Thesaurus Topics

  • Air Force
  • Air Force Facilities
  • Biology
  • Boundaries
  • Brain
  • Genetics
  • Genotypes
  • Implantation
  • Mutations
  • Neurosciences
  • Oscillators
  • Transplantation
  • Transplants
  • Universities
  • Virginia

Fields of Study

  • Biology

Readers

  • Circadian Sleep-Wake Regulation and Chronobiology
  • Molecular Genetics

Technology Areas

  • Biotechnology