Synthetic Vaccines for the Control of Arenavirus Infections.
Abstract
During the contract year August 1, 1990 through July 31, 1991, we made substantial progress in several important aspects of our goal to define a strategy to employ synthetic vaccine strategies to immunization against arenavirus infections: (1) Refinements of our model of the arenavirus spike structure to include the GP-l/GP-2 interaction and the predicted conformation of GP-2 and its interaction an on with the membrane and viral nucleocapsid core. (2) To define the ionic bonding interaction between GP-1 and GP-2 that stabilizes the tetrameric spike. (3) Refinement and extension of the antibody- mediated protection demonstrated against acute LCMV infection. Mice; Lab animals; RAI; BD; Arenavirus; Glycoprotein; Peptide; Vaccine; Biotechnology; C DNA; Lassa; Plasmids.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 22, 1991
- Accession Number
- ADA250872
Entities
People
- Michael J. Buchmeier
Organizations
- Scripps Research