Design and Synthesis of Molecular Systems Capable of Supporting Intracavity Chemical Reactions
Abstract
This project involves the synthesis of molecules containing concave functional groups capable of supporting chemical reactions. Salient sub-problems have to do with the distinction between steric encumbrance and steric hindrance, and with development of well documented intracavity covalent bond-forming reactions. Host molecules bearing functional groups capable of hydrogen bond formation, metal ion complexation, and aldimine condensation are of primary interest, their functional groups being in a sterically encumbered but not hindered environment. The structural motif involves construction of cyclophanes bearing the desired reactive group oriented in an inward-pointing manner, in combination (optionally) with structural features that enhance binding of the external co-reactor.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 13, 1992
- Accession Number
- ADA251024
Entities
People
- Howard W. Whitlock Jr