Pathophysiologic Mechanisms of Three Pulmonary Edemagenic Compounds: The Role of Toxic Oxygen Species.
Abstract
Inhalation of phosgene (CG), perfluoroisobutylene (PFIB), or bis(trifluoromethyl)disulfide (TFD) results in the production of pulmonary edema, but the mechanism involved has not been determined. To study this mechanism, the effects of eight drugs thought to affect the development of this type of edema were studied in rats exposed to-these gases. The compounds included N-acetylcysteine (thiol), ibuprofen (cyclooxygenase inhibitor), pentigetide (inflammation modulator), lodoxamide (xanthine oxidase inhibitor). and hydroxyurea (neutrophil depleter) and three lazaroids (two 21-aminosteroids and one 2-methylaminochroman). The protection from lung toxicity that was found, if any, varied according to the drug used, gas involved and timing of drug administration. Although the results are consistent with a mechanism of toxic gas lung injury involving toxic oxygen radicals, other mechanisms are not excluded. In Phosgene, Perfluoroisobutylene, Bis(trifluoromethy Rats, Pulmonary Edema
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 1992
- Accession Number
- ADA251135
Entities
People
- Holcombe H. Hurt
- Jill R. Keeler
- Suzanne A. Hernandez
- Theresa M. Tezak-reid
- Wallace B. Baze
Organizations
- United States Army Medical Research Institute of Chemical Defense