Limited Toxicity and Mutagenicity Testing of Five Unicharge Propellant Compounds

Abstract

N-methyl-, n-ethyl- and n-butyl-2nitratoethyl nitramine (MeNENA, EtNENA and BuNENA) and bis (2,2-dinitropropyl) acetal/formal (-50/50 mixture) +/- diphenyl amine stabilizer (BDNPA/F+/-DPA) were tested for delayed contact hypersensitivity in the Buehler Assay. Three groups of guinea pigs per study received the test article, positive or negative control by topical application once per week for a total of three six-hour insult periods. Fourteen days after the last induction all animals were challenged at a naive site. Desired responses were elicited in the negative and positive control groups. No responses were observed after challenge in any test animal. Based upon the results of these assays, MeNENA, ETNENA, BuNENA, BDNPA/F+/-DPA did not cause dermal sensitization in guinea pigs. Beuhler Assay, Unicharge, Propellants, Methyl-NENA, Ethylbutyl-NENA, Bis-(2,2-dinitropropyl)acetal, Bis-(2,2 dinitropropyl) acetal, Bis-(2,2-dinitropropyl) formal, Lab animals, RAIII.

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Document Details

Document Type
Technical Report
Publication Date
Jan 31, 1992
Accession Number
ADA251416

Entities

People

  • Susan E. Armondi
  • Vincent B. Ciofalo

Tags

DTIC Thesaurus Topics

  • Amines
  • Animals
  • Biomedical Research
  • Body Weight
  • Environmental Protection
  • Eukaryotes
  • Hypersensitivity
  • Laboratory Animals
  • Materials
  • New York
  • Propellants
  • Range Finding
  • Recombinant Dna
  • Research Facilities
  • Rodents
  • Test And Evaluation
  • Test Facilities

Readers

  • Toxicology/Environmental Toxicology