Limited Toxicity and Mutagenicity Testing of Five Unicharge Propellant Compounds

Abstract

Bis (2,2-dinitropropyl) acetal/formal (-50/50 mixture) +/diphenyl amine stabilizer (BDNPA/F+/-DPA) were tested for dermal irritation. one group of six rabbits per study were dermally exposed to the test article for four hours. Animals were observed for erythema and edema at 30-60 minutes, 24, 48 and 72 hours after dosing. Based upon the results of these assays, BDNPA/F+DPA and BDNPA/F-DPA were determined to be non-irritants. (Primary Dermal Irritation Index for both test articles=O.O) The Dermal Irritation Toxicity Category for both test articles is Class Iv. Dermal irritation, Unicharge, Propellants, Bis- (2,2dinitropropyl)acetal, Bis-(2,2-dinitropropyl) formal, Lab animals, RAIII.

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Document Details

Document Type
Technical Report
Publication Date
Jan 31, 1992
Accession Number
ADA251421

Entities

People

  • Victor T. Mallory
  • Vincent B. Ciofalo

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Animals
  • Bandages
  • Biomedical Research
  • Body Weight
  • Irritants
  • Irritation
  • Laboratory Animals
  • Materials
  • Observation
  • Propellants
  • Recombinant Dna
  • Research Facilities
  • Skin Diseases
  • Test And Evaluation
  • Test Facilities
  • Toxicity

Readers

  • Toxicology/Environmental Toxicology