Limited Toxicity and Mutagenicity Testing of Five Unicharge Propellant Compounds

Abstract

n-Methyl-, n-ethyl- and n-butyl-2-nitratoethyl nitramine (Me, Et, and BuNENA), and bis-(2,2-dinitropropyl) acetal/formal (-50/50 mixture; +/-diphenyl amine stabilizer; BDNPA/F +/-DPA), were tested in the Ames/Salmonella assay in strains TA1535, TA1537, TA1538, TA98 and TA100 up to a maximum of 10,000 Ag/plate or a toxic limit with and without metabolic activation (+/-S9). All samples induced reproducible, significant, dose-dependent, 2.6- to 20-fold increases in revertant frequencies in strain TA1535 +S9. Similar 1.6- to 10fold increases were observed for MeNENA, EtNENA and BDNPA/F +/-DPA in TA1535 -S9. Significant and/or dose-dependent increases, to 1.3to 3.1-fold control values, were reproducibly observed in TA100 for BDNPA/F +/-DPA +/-S9, and for EtNENA +s9. All other sample/strain/S9 combinations produced negative results. On the basis of results in strain TA1535 with S9, the rank order of mutagenic potential is EtNENA > BuNENA > BDNPA/F +DPA = BDNPA/F -DPA >> MeNENA. methyl-NENA, ethyl- NENA, butyl-NENA, bis-(2,2-dinitropropyl) acetal, bis-(2,2dinitropropyl) formal, RA III, lab animals Ames/Salmonella assay, unicharge propellants.

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Document Details

Document Type
Technical Report
Publication Date
Dec 06, 1991
Accession Number
ADA251422

Entities

People

  • Leon F. Stankowski
  • Vincent B. Ciofalo

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Animals
  • Biomedical Research
  • Chemistry
  • Data Acquisition
  • Environmental Protection
  • Frequency
  • Laboratory Animals
  • Materials
  • Molecular Weight
  • Mutagenicity Tests
  • Sodium Azides
  • Sodium Compounds
  • Standards
  • Statistical Analysis
  • Test And Evaluation
  • Test Facilities
  • Test Methods

Readers

  • Analytical Chemistry
  • Toxicology/Environmental Toxicology