Limited Toxicity and Mutagenicity Testing of Five Unicharge Propellant Compounds.
Abstract
n-Methyl-,n-ethyl- and n-butyl-2-nitratoethyl nitramine (MeNENA, EtNENA, and BuNENA), and bis- (2,2- dinitropropyl) acetal/formal (-50/50 mixture; +/- diphenyl amine stabilizer; BDNPA/F+/-DPA), were tested in the in vitro SCE assay in CHO cells to a maximum of 5000 ug/ml or a toxic limit with and without a metabolic activation system (S-9 mix). ETNENA and BDNPA/F+DPA induced statistically significant, dose-related increases in SCE frequencies without S-9 mix, but only ETNENA induced two-fold increases (3.6-fold) over the negative control. MeNENA, ETNENA and BuNENA induced statistically significant, dose-related, 5.0to 6.2-fold increases in SCE frequencies with S-9 mix. Both BDNPA/F+/-DPA induced statistically significant increases at several dose points, however, they were not two-fold increases at any dose. On the basis of these results, the rank order of SCE inducers is EtNENA>BuNENA>MeNENA>BDNPA/F+DPA=BDNPA/F-DPA. HO assay, unicharge propellants, methyl-NENA, ethyl-NENA, butyl-NENA, bis-(2,2-dinitropropyl)acetal, bis-(2,2dinitropropyl) formal, lab animals, RAIII
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 21, 1992
- Accession Number
- ADA251423
Entities
People
- Vincent B. Ciofalo