Discovery and Development of Therapeutic Drugs Against Lethal Human RNA Viruses: A Multidisciplinary Assault.

Abstract

Continuation of a vigorous investigation sharply focused on the isolation, characterization and structural elucidation of new and potentially useful antiviral drugs from marine animals and plants was pursued. The renewal approval allowed further progress toward the isolation and characterization of novel antiviral substances from confirmed active extracts of marine organisms and both higher and lower plants. The synthetic studies with narciclasine was continued and the supply of pancratistatin from both semi-synthetic and botanical sources was studied further. RNA Viruses; Antiviral Drug Discovery; Pancratistatin and related antiviral leads; RA I; BD; Natural Products

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Document Details

Document Type
Technical Report
Publication Date
Mar 17, 1992
Accession Number
ADA251561

Entities

Organizations

  • Arizona State University

Tags

DTIC Thesaurus Topics

  • Antiviral Agents
  • Arbovirus Infections
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Chemotherapy
  • Mass Spectrometry
  • Materials
  • Medical Personnel
  • Organic Chemistry
  • Rna Viruses
  • Virus Diseases
  • Viruses

Readers

  • Allergy and Immunology.
  • Aquatic Ecology
  • Molecular and Cellular Biochemistry